Presented by Prof. Adrian Canavesi: Middle-aged patient 42 with MEN IIb syndrome, s/p thyroidectomy about 10 years ago for medullary thyroid cancer, s/p bilateral adrenalectomy due to pheochromocytoma one year later. Since then, taking hydrocortisone and fludrocortisone. About 5 years underwent subtotal colectomy due to intestinal obstruction and megacolon. Immunohistochemistry was performed, being positive for S100, which was diagnostic of intestinal ganglioneuromatosis.